SPRITAM is manufactured with US-sourced levetiracetam by Aprecia Pharmaceuticals, LLC in Blue Ash, Ohio USA. The manufacturing facility is the first and only in the world to receive FDA authorization to produce a three-dimensionally printed pharmaceutical product for commercial sale in the United States.

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Why Choose SPRITAM?

SPRITAM® (levetiracetam) Tablets for Oral Suspension is an oral prescription medicine in a flash-dispersing formulation for certain types of epilepsy that your patients may find surprisingly easy to take.11. Boudriau S, Harvey C, Massicotte J, et al. Randomized Comparative bioavailability of a novel three-dimensional printed fast-melt formulation of levetiracetam following the administration of a single 1000-mg dose to healthy human volunteers under fasting and fed conditions, Drugs R D. 2016;16(2):229–238. SPRITAM is approved to treat 2SPRITAM Full Prescribing Information. Aprecia Pharmaceuticals Company. :

  • Partial-onset seizures as a monotherapy treatment in patients 4 years of age and older weighing more than 20 kg (44 pounds)
  • Myoclonic seizures as an adjunctive therapy in patients 12 years of age and older with juvenile myoclonic epilepsy
  • Primary generalized tonic-clonic seizures in patients 6 years of age and older weighing more than 20 kg (44 pounds) with idiopathic generalized epilepsy.

SPRITAM is an orodispersible formulation of levetiracetam.22. SPRITAM Full Prescribing Information. Aprecia Pharmaceuticals Company. Levetiracetam is a medication that patients with epilepsy and their healthcare providers have relied on for more than 15 years.3, 3. National Institute for Health and Care Excellence. The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. 2015;137:1–117.4Lyseng-Williamson KA. Spotlight on levetiracetam in epilepsy. CNS Drugs. 2011;25(10):901–905. While levetiracetam is available as conventional tablets, SPRITAM is the first and only FDA-approved medicine manufactured using 3D printing (3DP). The combination of 3DP technology and formulation science helps enable certain features:

Rapidly disintegrates* in your mouth with just a sip of liquid2SPRITAM Full Prescribing Information. Aprecia Pharmaceuticals Company.

*In a mean time of 11 seconds
(range of 2 to 27 seconds).

Masks the taste of levetiracetam1Boudriau S, Harvey C, Massicotte J, et al. Randomized Comparative bioavailability of a nocel three-dimensional printed fast-melt formulation of levetiracetam following the administration of a single 1000-mg dose to healthy human volunteers under fasting and fed conditions, Drugs R D. 2016;16(2):229–238.

Available in doses up to 1,000 mg2SPRITAM Full Prescribing Information. Aprecia Pharmaceuticals Company.

SPRITAM may be an appropriate option for your patients with certain types of epilepsy.2SPRITAM Full Prescribing Information. Aprecia Pharmaceuticals Company. Factors to consider may include whether your patients:

  • Struggle to swallow tablets or capsules
  • Dislike the texture and/or taste of liquid medicine
  • Have trouble accurately measuring precise doses of liquid medicine
  • Are interested in an epilepsy medication that they may find surprisingly easy to take
    1Boudriau S, Harvey C, Massicotte J, et al. Randomized Comparative bioavailability of a nocel three-dimensional printed fast-melt formulation of levetiracetam following the administration of a single 1000-mg dose to healthy human volunteers under fasting and fed conditions, Drugs R D. 2016;16(2):229–238.

Worth Remembering

In a crossover study in healthy adults under fasting conditions, SPRITAM administered with a sip of water was shown to have an equivalent rate and extent of absorption to levetiracetam immediate-release tablets.2SPRITAM Full Prescribing Information. Aprecia Pharmaceuticals Company.